Codeine Phosphate 30 mg


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Codeine Phosphate 30 mg

Codeine Phosphate 30 mg. Codeine is an alkaloid obtained from opium or prepared from morphine by methylation and occurs as white crystals. Codeine effloresces slowly in dry air and is effected by light. The chemical name of codeine phosphate is 7,8-Didehydro-4,5alpha-epoxy-3-methoxy-17-methylmorphinan-6alpha-ol phosphate (1:1)(salt) hemihydrate and has the empirical formula of C18H21NO3·H3PO4·1/2H20. Its molecular weight is 406.4.

Codeine is a evidently taking place alkaloid of opium and the world over the standard susceptible opioid (global fitness organization 1996). it’s far metabolized within the liver frequently through glucuronidation,N-demethylation, andO-demethylation. The latter method thru cytochrome P450 2D6 is accountable for the transformation to morphine (2–10% of the codeine dose) (Lotsch 2005), the analgesic metabolite of codeine, which itself is devoid of analgesic properties. this limits the medical usefulness of codeine due to the fact around nine% of Caucasians are deficient in this isoenzyme and derive no analgesic benefit from codeine (Stamer and Stuber 2007b). on the other hand, a few human beings are ultrarapid metabolizers who showcase high morphine stages after the intake of codeine (Kirchheiner et al 2007); the share of such metabolizers relies upon on ethnicity, with up to 29% of a few center jap and North African populations but most effective zero.five% of some Asian populations being affected. This allele poses a threat to breastfed newborns, who can be uncovered to doubtlessly lifestyles-threatening morphine tiers (Madadi et al 2009). Codeine Phosphate 30 mg

The oral bioavailability of codeine phosphate is variable and the period of movement of an oral dose is four–6 hours. it’s far generally utilized in doses of 30–120 mg each 4 hours. Codeine, 60 mg, is a totally bad analgesic via itself, with a combined variety had to treat (NNT) of 12 for at the least 50% pain alleviation (Derry et al 2010). but, codeine improves the analgesic efficacy of non-opioids; with the addition of 60 mg codeine, the NNT of one thousand mg paracetamol improves from 3.8 to two.2 and its length of analgesia is extended (Toms et al 2009). Constipation is a primary adverse impact of codeine.

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